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The reason THC-rich strains of cannabis produce psychotropic side effects is because THC binds with CB1 receptors in parts of the brain linked to mood and motivation. When you consider the number of receptors in the body, and the number of cannabinoids discovered so far, it's easy to understand why their role in human wellness is significant. There could be thousands of lock and key combinations and thousands of different biological reactions as a result. For example, the reason THC produces a high is because it fits the lock of CB1 receptors in parts of the brain linked to emotion and perception.